… is a frequently used therapeutic option for patients with MGD when mechanical treatment
modalities are not sufficient to reach … are poorly lipophilic and therefore do not reach high tissue …

… oral administration of doxycycline results in detectable tear film concentrations in dogs
reaching … Oral doxycycline administration only achieves a tear concentration of 0.43 μg/mL 9 to …

… tear film. The depleted meibum results in increased tear evaporation, tear hyperosmolarity,
tear film … concentration level in the tears might not reach an inhibitory concentration with oral …

… ); the other parameters did not reach statistical significance. … to receive once-daily oral
administration of either isotretinoin … gland production and increase tear film stability; various …

… tear film. Moreover, the topical azithromycin group seemed to be superior over the oral
doxycycline group in improving the quality of tear film … could not reach the therapeutic level on the …

… TBUT and meibomian gland expression compared to systemic doxycycline (Group B) (p<…
to systemic doxycycline. The localized action and superior outcomes in tear film stability and …

… doxycycline is mediated by a large number of mechanisms. The anti-inflammatory effects of
doxycycline … The same effect could not be achieved with the oral administration of doxycycline…

… doxycycline is mediated by a large number of mechanisms. The anti-inflammatory effects of
doxycycline … The same effect could not be achieved with the oral administration of doxycycline…

… tear film pharmacokinetics following topical administration of … of an eye drop that reaches
the systemic circulation in dogs. … oral administration of prednisone (0.5–4.0 mg/kg) (18), tear …

… For instance, oral doxycycline can be used as adjunctive … in tear fluid of dogs following
oral administration at doses … The present study describes, for the first time, the tear film PK of …